Natalie (Elisabeth Harnois) is high school royalty, but her queen bee status falls apart when she falls for the new guy at school. Although Keith (Jesse McCartney) ignores her at first, they soon become friends -- even though Natalie suspects that Keith has something to hide. As the free-spirited Keith shows Natalie how to embrace what life offers, they grow closer -- until a secret tests the bounds of their relationship
A plane is taken over by a mysterious virus. When the plane lands it is placed under quarantine. Now a group of survivors must band together to survive the quarantine.